Delayed-type hypersensitivity (DTH) is defined as the recruitment of T cells into tissues to be activated by antigen-presenting cells to produce cytokines that mediate local inflammation. CD8+ T cells are now known to mediate DTH responses in allergic contact dermatitis, drug eruptions, asthma, and autoimmune diseases. This inflammatory effector capability of CD8+ cytotoxic T cells was previously poorly recognized, but there is now considerable evidence that these diseases may be mediated by CD8+ DTH. The difference between CD8+ T cells and CD4+ T cells mediating DTH relates to the molecular mechanisms by which antigens are processed and presented to the T cells. Antigens external to the cell are phagocytosed and processed for presentation on MHC class II molecules (eg, HLA-DR) to CD4+ T cells. In contrast, internal cytoplasmic antigens are processed by the endogenous pathway for presentation on MHC class I molecules (eg, HLA-A, -B, and -C) to CD8+ T cells. External allergens can also enter the endogenous pathway to be presented to CD8+ T cells. These include many contact sensitizers, chemical and protein respiratory allergens, viral antigens, metabolic products of drugs, and autoantigens. The resulting CD8+ T-cell response explains the role of CD8+ T-cell DTH mechanisms in allergic contact dermatitis, asthma, drug eruptions, and autoimmune diseases.
so, this is the abstract of the journal that was given by our immunology lecturer as a souvenir before immunology paper this 10th nov. 8 pages of journal is a lot actually. and i have to do a summary about the reading in not more than 3 pages. macam senang kan? haa, you try first. i generously give you the link for full text version. basically, it is all about immune system, MHC class I, MHC class II, autoimmune system, asthma, allergy, CD4+, CD8+. you have this things in your body, no matter who you are.
please, don't hesitate to visit and READ. it is amazingggg! how i define amazing? you take a look at it first, then you know how amazing it is. i did it for 4hours. of course with some facebook-ing, blog-walking, eating, bbm-ing, etc.
my eyes seriously can't stand reading pages of words anymore. after struggling reading 4 articles during the exam, and just now the journal, my eyes, my neck, my shoulder became like #$(&%@^&!! (i don't know the name of the feeling).
at least for a week. (notes for exam is acceptable. well, terpaksa).
i bet you wouldn't read this journal. if anyone of you did it, you tell me. i will give you special reward,hehe.
i know, i know this is B-O-R-I-N-G
i won't post something like this again. i try! after all, this is my field. no matter how boring it is, i still have to be friend with them. with bright smile of course. -___________-"
--> i went to KOS (kuliyyah of science) right after the exam to check my marks for immunology quiz. surprisingly, i got quite high marks for that quiz!! yeay for dhiya, yeayy!!! :D i never had such high marks for quizzes so far this semester. ALHAMDULILLAH :") now i'm eager to study immunology for final exam. ahh, xsangka~~
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